5 edition of Corticotropin-releasing factor found in the catalog.
|Statement||[editors, Derek J. Chadwick, Joan Marsh, and Kate Ackrill].|
|Series||Ciba Foundation symposium ;, 172|
|Contributions||Chadwick, Derek., Marsh, Joan., Ackrill, Kate., Symposium on Corticotropin-Releasing Factor (1992 : Ciba Foundation)|
|LC Classifications||QP572.C62 C66 1993|
|The Physical Object|
|Pagination||x, 357 p. :|
|Number of Pages||357|
|LC Control Number||92036532|
The corticotropin-releasing factor (CRF, also known as corticotropin-releasing hormone, or corticoliberin) is a hypothalamic hormone controlling the synthesis of POMC in the pituitary and is the. hormone [hor´mōn] a chemical transmitter substance produced by cells of the body and transported by the bloodstream to the cells and organs on which it has a specific regulatory effect. adj., adj hormo´nal. Hormones act as chemical messengers to body organs, stimulating certain life processes and retarding others. Growth, reproduction, control of.
The goal of this article is to summarize available data examining the physiological significance of brain corticotropin-releasing factor (CRF) systems in mediating the behavioral and physiological effects of several classes of abused drugs, including opioid and psychostimulant drugs, alcohol and sedative hypnotics, nicotine, and by: No organ in the body is impervious to the effects of stress, and a coordinated response from all organs is essential to deal with stressors. A dysregulated stress response that fails to bring systems back to homeostasis leads to compromised function and ultimately a diseased state. The components of the corticotropin-releasing factor (CRF) family, an ancient and evolutionarily conserved stress.
Corticotropin-releasing hormone (CRH; ), also called corticotropin-releasing factor (CRF), is a amino acid peptide synthesized in the hypothalamus and capable of stimulating the production of adrenocorticotropic hormone (ACTH) and other proopiomelanocortin products of the anterior ic, functional, and pharmacologic studies have suggested numerous physiologic roles . : Corticotropin Releasing Factor Antibody: Industrial & Scientific. Skip to main content. Try Prime Industrial & Scientific Go Search EN Hello, Sign in Account & Lists Sign in.
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Corticotropin-releasing factor (CRF) is a residue polypeptide originally isolated from ovine hypothalamic extracts and characterized as the principal secretagogue of adrenocorticotropin hormone by Vale et al. 1 The biological actions of CRF are mediated through two G protein–coupled receptors, CRF R1 and CRF R2, both of which have multiple.
This book provides a comprehensive summary of data from basic and clinical studies in support of a role for corticotropin-releasing factor (CRF) as a neurotransmitter in the mammalian central nervous system (CNS).Cited by: 1.
Corticotropin-releasing hormone (CRH), a peptide hormone that stimulates both the synthesis and the secretion of adrenocorticotropic hormone (ACTH) in the corticotropin-producing cells (corticotrophs) of the anterior pituitary consists of a single chain of 41 amino factors of neuronal and hormonal origin regulate the secretion of CRH, and it is the final common element.
corticotropin-releasing factor: a factor secreted by the hypothalamus that stimulates the pituitary to release adrenocorticotropic hormone. Synonym(s): corticotropin-releasing factor. Corticotropin-releasing factor book A.J.
Dunn --Central actions of corticotropin-releasing factor on autonomic nervous activity and cardiovascular function / L.A. Fisher --Peripheral anti-inflammatory actions of corticotropin-releasing factor / E.T.
Wei, G.C. Gao and H.A. Thomas --Role of corticotropin-releasing factor in behavioral responses to stress / G.F. Koob [and others. ISBN: OCLC Number: Description: pages: illustrations ; 26 cm: Contents: Cloning and Distribution of Expression of. Corticotropin releasing factor (CRF) is a neuropeptide that is a major regulator of the hypothalamic-pituitary-adrenal system.
Recent findings have shown that CRF exists in extrahypothalamic areas in the brain as well as in the hypothalamus, and extrahypothalamic CRF Cited by: 8.
This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone.
In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone.
Corticotropin-releasing factor (CRF, nomenclature as agreed by the NC-IUPHAR subcommittee on Corticotropin-releasing Factor Receptors ) receptors are activated by the endogenous peptides corticotrophin-releasing hormone (CRH, P), a 41 amino-acid peptide, urocortin 1 (UCN, P), 40 amino-acids, urocortin 2 (UCN2, Q96RP3), 38 amino-acids and urocortin 3 (UCN3, QE3), 38.
About this book Working on Corticotropin-Releasing Factor in a variety of systems, experts present a coherent depiction of this peptide's role in the control and coordination of the response to stress-inducing situations.
Define corticotropin releasing factor. corticotropin releasing factor synonyms, corticotropin releasing factor pronunciation, corticotropin releasing factor translation, English.
A decade prior to elucidation of the sequence of corticotropin-releasing factor (CRF), investigators were already studying the neurotransmitter regulation of CRF release in vitro using bioassays for adrenocorticotropin (ACTH) and adrenal glucocorticoids as a measure of "CRF" : Michael J.
Owens, Charles B. Nemeroff. The unique distribution of corticotropin‐releasing factor (CRF) and its receptors within the central nervous system, its pre‐eminent role in mediating the endocrine, behavioural, autonomic and immunological effects of stress and its potent effects after direct administration into the CNS all support the hypothesis that alterations in CRF neuronal systems contribute to the pathophysiology Cited by: AB - Corticotropin-releasing factor (CRF) is a 41 amino acid peptide (i.e., small protein) that plays an integral role in modulating the stress response in humans.
CRF was first isolated for its role in regulating pituitaryadrenal axis activity by modulating the release of adrenocorticotropic hormone (ACTH) Author: D.
Gutman, Charles Nemeroff. This book provides a comprehensive summary of data from basic and clinical studies in support of a role for corticotropin-releasing factor (CRF) as a neurotransmitter in the mammalian central nervous system (CNS).
It includes descriptions of the anatomy of CRF and its receptors in the CNS, as well as the characterization of CRF receptors and the second messenger systems mediating effects of.
T1 - The Corticotropin Releasing Factor System and Alcohol Consumption. AU - Ryabinin, Andrey. AU - Giardino, William J. PY - /1/1. Y1 - /1/1. N2 - Excessive alcohol consumption leading to dependence is accompanied by adaptive changes in neurocircuits regulating reward, mood, and stress : Andrey E.
Ryabinin, William J. Giardino. Corticotrophin-releasing hormone is the main element that drives the body's response to stress.
It is also present in diseases that cause inflammation. Too much or too little corticotrophin-releasing hormone can have a range of negative effects. Another recent finding related to addiction is the modulating influence of a variety of stress-related neuropeptides, particularly a corticotropin-releasing factor that has been shown to increase dopamine release in the nucleus accumbens during the development of addictive behaviors (Sinha, ).
Introduction. Corticotropin-releasing factor (CRF), also known as corticotropin-releasing hormone (CRH), orchestrates the stress response in the endocrine, autonomic, immune, and behavioral systems through the activation of the hypothalamic–pituitary–adrenal (HPA) axis and extrahypothalamic pathways.
A total of OF1 mice were divided into experimental groups according to the treatment received before each social defeat: saline, 5 or 10mg/kg of the nonpeptidic corticotropin-releasing factor. Abstract. Corticotropin-releasing factor (CRF) is known to exert potent activating effects on the pituitary-adrenal axis is presumably the long sought-after hypothalamic neurohumor bestowed with the specific function of releasing adrenocorticotropin hormone (ACTH) from the anterior pituitary, and thus may be considered the final common pathway for the neurohumoral control of by: 8.The corticotropin-releasing factor stimulation test.
An aid in the evaluation of patients with Cushing's syndrome. N Engl J Med ; DeCherney GS, DeBold CR, Jackson RV, et al. Diurnal variation in the response of plasma adrenocorticotropin and cortisol .‘Corticotropin releasing factor is a critical integrator of the hypothalamic-pituitary-adrenal axis in response to stress.’ ‘Like depression, post-traumatic stress disorder is associated with increased secretion of corticotropin releasing factor.’.